Chitosan oligosaccharide,chito-oligosaccharide
Chitosan oligosaccharide
CAS: 148411-57-8
Molecular Formula: C12H24N2O9
Chitosan oligosaccharide,chito-oligosaccharide - Names and Identifiers
Chitosan oligosaccharide,chito-oligosaccharide - Physico-chemical Properties
| Molecular Formula | C12H24N2O9 |
| Molar Mass | 340.32696 |
| Solubility | Soluble in water |
| Appearance | Powder |
| Storage Condition | 2-8℃ |
| Sensitive | Easily absorbing moisture |
| In vitro study | Chitosan oligosaccharide (COS) represents a class of natural polymers that holds therapeutic promise in several diseases due to not only its physiochemical properties including water-solubility and low viscosity but also its favorable pharmacological properties including good pharmacokinetics and safety profiles and diverse beneficial biological activities. Activation of AMPK and inhibition of inflammatory signaling pathways including NF-κB and MAPK pathways are recognized as major mechanisms responsible for several effects of Chitosan oligosaccharide (COS) including anti-inflammation, anti-cancer, and anti-diabetes. COS can interrupt cancer progression at multiple stages by modulating several signaling proteins/pathways including NF-κB, AMPK, mTOR, caspase-3, CD147, MMP-2, MMP-9, and VEGF. In vitro experiments have demonstrated that Chitosan oligosaccharide (COS) induced the death of several cancer cell types including ascites, bladder cancer, prostate cancer, lung cancer, liver cancer, leukemia, cervical cancer and colorectal cancer. The values of IC 50 of Chitosan oligosaccharide (COS) in inducing cytotoxicity are 25 μg/mL-50 μg/mL depending on types of cancer cells. |
| In vivo study | The oral administration of Chitosan oligosaccharide (16 mg/kg/day) suppresses the production of the proinflammatory cytokines involved in allergic reactions, i.e., IL-4, IL-13 and TNF-α, in the lung tissues and bronchoalveolar lavage fluid of the mice. Last, an anti-inflammatory effect of Chitosan oligosaccharide (COS) on lymphocyte activation has been documented in a rat model of autoimmune anterior uveitis induced by immunization with bovine melanin-associated antigen. Chitosan oligosaccharide (COS) inhibits UV-induced macroscopic appearance in mice skin. Compared with healthy dorsal skin with smoothness and some shallow wrinkles of hairless mice in normal control group, UV exposure for 10 weeks triggers skin erythema, dry, thickening, sagging and coarse wrinkles, and even leathery appearance and slight flesh-colored lesion in the model mice, the visual score of which is markedly higher than that of the normal control group (p<0.05), indicating that UV induces photoaging in skin surface. |
Chitosan oligosaccharide,chito-oligosaccharide - Risk and Safety
| WGK Germany | 3 |
Chitosan oligosaccharide,chito-oligosaccharide - Reference
| Reference Show more | 1. Wu Qian, Luo Jianquan, Li Su Shuang, etc. Application of adsorption membrane based on polydopamine coating in removal of aflatoxin [J]. Membrane Science and Technology, 2019, v.39;No.196(03):91-101. 2. Yang qiangjian, Luo Jianquan, Guo Shiwei, etc. Control of membrane fouling in treating molasses with polyethersulfone ultrafiltration membrane [J]. Membrane Science and Technology, 2019. 3. Zhou Wei, Hu Yi, Zhang Jinjie, etc. Synergistic modification of fish scale gelatin edible film by myricetin and glycosylation [J]. Food and Fermentation Industry, 2018, 44(006):58-66. 4. Lin-Ming Xu. Synthesis and characterization of N-doped chitosan oligosaccharide-based porous carbon materials [D]. Guizhou University, 2020. 5. Jinfeng Mei, Hui Zhang, Zhongyu Li, Hongxiang Ou,A novel transport endoscope crosslink chitosan oligosac fluid for total tolerance of Cr(VI), Volume Polymers, 224,2019,115154,ISSN 0144-8617,https://doi.org/10.1016/j.carbpo 6. [IF=9.381] Jinfeng Mei et al."Prominent adsorption of Cr(VI) with graphene oxide aerogel twined with creeper-like polymer based on chitosan oligosaccharide."Carbohyd Polym. 2020 Nov;247:116733 7. [IF=9.381] Jinfeng Mei et al."A novel tetraethylenepentamine crosslinked chitosan oligosaccharide hydrogel for total adsorption of Cr(VI)."Carbohyd Polym. 2019 Nov;224:115154 8. [IF=5.268] Yabo Fu et al."Preparation and performance of a BTDA-modified polyurea microcapsule for encapsulating avermectin."Colloid Surface B. 2019 Nov;183:110400 9. [IF=3.693] Mei Qixiang et al."Porous COS@SiO2 Nanocomposites Ameliorate Severe Acute Pancreatitis and Associated Lung Injury by Regulating the Nrf2 Signaling Pathway in Mice."Front Chem. 2020 Oct;0:720 10. [IF=3.298] Guangben Wei et al."Immune effect of Vibrio harveyi formalin-killed cells vaccine combined with chitosan oligosaccharide and astragalus polysaccharides in♀Epinephelus fuscoguttatus×♂Epinephelus lanceolatus."Fish Shellfish Immun. 2020 Mar;98:186 11. [IF=3.196] Zhongxin Yang et al."Fabrication of KDF-loaded chitosan-oligosaccharide-encapsulated konjac glucomannan/sodium alginate/zeolite P microspheres with sustained-release antimicrobial activity."J Mol Struct. 2022 Feb;1250:131682 12. [IF=1.748] Yilin Zhang et al."The effect of chitosan oligosaccharide as an immune enhancer against Vibrio harveyi in pearl gentian grouper (♀Epinephelus fuscoguttatus ×♂Epinephelus lanceolatus)."Aquac Res. 2021 Feb;52(2):541-546 13. [IF=4.35] Peilong Liao et al."The Layered Encapsulation of Vitamin B2 and β-Carotene in Multilayer Alginate/Chitosan Gel Microspheres: Improving the Bioaccessibility of Vitamin B2 and β-Carotene."Foods. 2022 Jan;11(1):20 14. [IF=4.598] ZhongXin Yang et al."Construction of sodium alginate/konjac glucomannan/chitosan oligosaccharide/Zeolite P hydrogel microspheres loaded with potassium diformate for sustained intestinal bacterial inhibition."EUROPEAN POLYMER JOURNAL. 2022 Jun;172:111233 |
Chitosan oligosaccharide,chito-oligosaccharide - Reference Information
| Overview | Food-grade chitooligosaccharides, also known as chitooligosaccharides, it is a kind of oligosaccharide product with a degree of polymerization between 2 and 20, which is degraded by special biological enzyme technology (also reported by chemical degradation and microwave degradation technology). The molecular weight is less than or equal to 3200Da, it is a low molecular weight product with good water solubility, large function and high biological activity. It has a high solubility of chitosan, soluble in water, easy to be absorbed by organisms and many other unique functions, its role is 14 times of chitosan. Food grade chitosan oligosaccharide is the only positive charge cationic basic amino oligosaccharide in nature, is animal cellulose. |
| properties | Food Grade chitooligosaccharides it is obtained from chitin or chitosan by enzymatic or chemical degradation. Food-grade chitosan oligosaccharide is the only natural sugar in the presence of a large number of alkaline polysaccharides, in addition to similar properties of chitosan, it also has low viscosity, good water solubility, small molecular weight, it is easy to absorb and degrade, and its biological activity and functional properties are more extensive than chitosan. |
| function | Food-grade chitooligosaccharide is an ideal bioactive substance, which can regulate blood glucose and blood lipid, resist oxidation, enhance immune and anti-tumor and other biological activities. Food-grade chitooligosaccharides have multiple and pleiotropic regulatory effects on the immune system. |
| Application | Food-grade chitooligosaccharides are oligosaccharides composed of 2-15 glucosamine units, A wide range of functions in areas such as light industry have been widely recognized in academia and markets. |
| biological activity | Chitosan oligosacclide (COS) is a kind of β-(1 → 4) an oligomer of glycosidic linked D-glucosamine. Chitosan oligosaccamide (COS) activates AMPK and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways. |
| Target | AMPK |
| Use | treatment of organic matter and heavy metal pollutants in water, biomedical devices, biodegradable packaging, water-permeable fabric finishing, cosmetics. |
Last Update：2024-04-09 21:54:55
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